BACKGROUND: Yacon is a root crop which contains high amounts of The aim of this study was to investigate the effects of yacon syrup on. Yacon roots (Smallanthus sonchifolius) improve oxidative stress in diabetic rats. Instituto Superior de Investigaciones Biológicas (INSIBIO). Carolina Serra-. Instituto Superior de Investigaciones Biológicas (INSIBIO), Another important Andean crop is yacon (Smallanthus sonchifolius) which is a.

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The body weight and body length were used to determine the following anthropometrical parameters: This may take some time to load. Yacon supplementation reduced the expression of the mentioned markers in HFD-fed animals Figures 4 a — 4 c.

The HFD group received a standard-based diet enriched with eatable lard and carbohydrates modified from [ 33 ] to induce obesity and hyperlipidemia. This work is licensed under a Creative Commons Attribution 4.

Cell Mol Life Sci Morphometric and Nutritional Determinations Animals were weighed g weekly throughout the experimental period. Tissue Sampling At the end of the experimental period, rats were fasted overnight and deeply anaesthetized with 1: Methods Enzyme Anal Yacon was well tolerated with an excellent side effect profile.

Acknowledgments This research was supported by PIP no. Assessment of insulin resistance and impaired glucose tolerance in lean women with polycystic ovary syndrome. Experiment 1 After 12 weeks on HFD or standard chow, the animals were randomly divided into the following groups according to the treatment with or without the addition of yacon flour as a dietary supplement for 8 weeks Figure 1.

Additionally, adiponectin and leptin have been implicated in adipose tissue dysfunction [ 6 ]. Yacon supplementation to diabetic rats produced a significant decrease in malondialdehyde levels in both liver Endl fructooligosaccharides as a potential novel source of prebiotics.

Effect of yacon (Smallanthus sonchifolius) on colonic transit time in healthy volunteers.

Ameliorating effect and potential mechanism of Rehmannia glutinosa oligosaccharides on the impaired glucose metabolism in chronic stress rats fed with high-fat diet. Biochemical Determinations Triglycerides and total cholesterol concentrations were determined by enzymatic colorimetric methods using available commercial kits Wiener lab Group, Argentina.


Back to tab navigation Download options Please wait Moreover, releasing GLP-1 from intestinal L-cells directly into the portal vein could also represent an additional mechanism related to yacon FOS-improved glucose homeostasis [ 55 ].

J Clin Lipid Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: In this way, we analyzed whether yacon could invetsigaciones inflammatory markers in visceral fat and serum.

We can help you send a request to the authors directly. Increased adiposity during obesity greatly influences insulin sensitivity, glucose and lipid metabolism, and inflammation [ 3845 ].

Dietary fiber and body weight. Biochemical parameters were determined in liver, kidney, and blood at the end of the experimental period. Open in a separate window. Additionally, yacon roots present strong antioxidant activity and anti-inflammatory effects preventing the risks associated with metabolic diseases [ 27 — 29 ].

Obesity results from an energy imbalance between calorie intake and energy expenditure. If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

Relationship between serum adiponectin and leptin concentrations and body fat distribution. An improvement in the morphometric parameters was also observed in supplemented rats Supplemental data, Table S1. Sign up for further access to Scientific Publications and Authors!

PPAR gamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control. Request Full Text Paper. Centro de Investigaciones e Innovaciones de la Agroindustria Peruana. Updates on obesity pharmacotherapy. High-fat diet is considered a direct cause in the development of dyslipidemia during obesity [ 3132 ].

Similar results were observed in kidney. The experimental animals were randomly divided into two groups: Antioxidant properties of sterilized yacon Smallanthus sonchifolius tuber flour.

Reductions in cholesterol have only been found with long-term feeding of oligofructose in relatively high doses [ 60 ]. Robinson belongs to a member of Asteraceae family, which ranges through the Andean region in South America [ 1415 ]. Food intakes were recorded daily as follows: In this sense, natural products provide a rich source for safe and effective therapeutic compounds with multiple mechanisms of action [ 1213 ].


Table 3 shows the effects of yacon flour consumption on relative organ weights. The cell biology of fat expansion. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. One of the mechanisms by which the yacon root triggers weight loss seems to be a decrease in energy intake, given our observation of a lower food intake after yacon supplementation. In accordance with this finding, fasting glucose, glucose tolerance, and insulin resistance were also improved being the blood glucose concentrations similar to those of the SD rats during the glucose challenges Figures 7 f and 7 g.

Effect of yacon (Smallanthus sonchifolius) on colonic transit time in healthy volunteers.

The cecum antioxidant activity ycaon incremented in rats fed with the experimental foods with respect to the control diets. Go to our Instructions for using Copyright Clearance Center page for details. Article in Diabetes Baynes JW et al.

These carboxylic acids, especially butyrate, are also capable of stimulating the L-cells of the intestinal mucosa increasing the secretion of gut hormones that are involved in appetite regulation [ 41 ]. Obesity is now considered as a chronic inflammatory state linked to an abnormal cytokine production and the activation of inflammatory signaling pathways in adipose tissue [ 135 ].

Experiment 2 In a second design, after 12 weeks rats which fed yacoj diet continued with the same chow, while animals under HFD were changed to a standard diet with or without yacon, according to the following scheme Figure 1.